![]() Tubbler labs full#50 clones reformatted into full IgG or whatever you need.Primary screening profile and sequences for up to eight plates of antibody variants (usually kinetics).Risk assessment, sequence, and structural characterization of your starting antibody.In addition to the lead molecule, a Tumbler campaign will yield these deliverables: Our proprietary process results in a comprehensive data set which eliminates liabilities, broadens your IP coverage, and introduces species cross-reactivity. Learn more What to Expect in a Tumbler Antibody Optimization Campaign Our projects have resulted in paratopes with up to 20 amino acids varied from starting antibody to final lead candidate, allowing us to span 10 years of viral evolution by modifying anti-SARS antibodies. Tumbler antibody optimization and the SuperHuman antibody library provide significant reach for target and paratope modulation. The Hunt for Therapeutic Antibodies for COVID-19 Tumbler can also engineer true bi-epitopic antibodies antibodies that bind to two different targets with the same paratope.Tumbler can engineer cross-reactivity to cynomolgus monkey and mouse.It’s common for our starting clones to have designated affinity and antibody specificity to the human variant of the target. Tumbler is a library-based approach and can perform various forms of modulations to the antibody and the generated paratope sequence space. Target and Paratope Modulation and Engineering Our team of experienced antibody scientists will be by your side to advise on the characteristics crucial to your desired therapeutic application. Tumbler provides optimization of your antibody candidate to select for desired characteristics and the removal of other characteristics critical to therapeutic success. Antibody Liability RemovalĮnsuring your candidate is ready for the clinic is one of the most challenging steps in antibody discovery. Tumbler - Rapid Optimizationįigure 2: Kinetics graph demonstrating the rapid optimization in antibody affinity Tumbler provides, over 10x greater binding activity in both cyno and human targets. Not only does Tumbler provide a single affinity-improved version, you will also receive an entire panel of antibodies with varying paratopes for you to analyze and select the best version. Tumbler provides an optimal affinity maturation tool that can increasing your antibody candidate’s binding as much as two log KD, or 130x improved. Antibody humanization with Tumbler far exceeds chimeric CDR grafting.įigure 1: Antibody lead candidate results from Tumbler that show the candidate is demonstrating greater than 90% human structural characteristics while retaining or improving antibody affinity. Your antibody is ‘tumbled’ through our proprietary technology, producing an antibody candidate that is identical to human antibody structure and behavior. What can Antibody Optimization do for Your Antibodies? 1. Tumbler can also be used to retrofit antibodies to cross to a new version of the original target providing an avenue to repurpose drug and lead candidates, creating a cost-effective route of drug discovery. Delivering fully-human therapeutic-ready antibodies improved for affinity, potency, cross-reactivity, specificity, and biophysical attributes. Tumbler is designed to enhance the therapeutic or diagnostic performance of any antibody candidate, regardless of format. Tumbler provides simultaneous, multi-factor antibody engineering and optimization for antibody candidates discovered from our antibody libraries, or from your own development. Our Commitment to Diversity, Equity & Inclusionįast, Robust Antibody Optimization With Tumbler.Agrochemical Testing Services for Approvals.Scientific Staffing, Training, & Operations Support.Scientific & Regulatory Advisory Services.Tungsten VHH Library for Nanobody Discovery.SuperHuman Antibody Library for Antibody Discovery.Cosmic Antibody Library for Antibody Discovery.Phage Antibody Discovery and Antibody Engineering Toggle menu.Biologics Discovery and Protein Engineering Toggle menu.Physical Characterization & Pharmaceutical Sciences. ![]()
0 Comments
Leave a Reply. |
AuthorWrite something about yourself. No need to be fancy, just an overview. ArchivesCategories |